genome search | EU-SAGE

Genome-editing techniques are promising tools in plant breeding. To facilitate a more comprehensive understanding of the use of genome editing, EU-SAGE developed an interactive, publicly accessible online database of genome-edited crop plants as described in peer-reviewed scientific publications.
The aim of the database is to inform interested stakeholder communities in a transparent manner about the latest evidence about the use of genome editing in crop plants. Different elements including the plant species, traits, techniques, and applications can be filtered in this database.
Regarding the methodology, a literature search in the bibliographic databases and web pages of governmental agencies was conducted using predefined queries in English. Identifying research articles in other languages was not possible due to language barriers. Patents were not screened.
Peer-reviewed articles were screened for relevance and were included in the database based on pre-defined criteria. The main criterium is that the research article should describe a research study of any crop plant in which a trait has been introduced that is relevant from an agricultural and/or food/feed perspective. The database does neither give information on the stage of development of the crop plant, nor on the existence of the intention to develop the described crop plants to be marketed.
This database will be regularly updated. Please contact us via the following webpage in case you would like to inform us about a new scientific study of crops developed for market-oriented agricultural production as a result of genome editing

Displaying 72 results

Traits related to biotic stress tolerance

Fungal resistance: enhanced resistance against rust caused by Puccinia striiformis f. sp. tritici and powdery mildew caused by Blumeria graminis f. sp. tritici., while also increasing yield.
(Liu et al., 2024)

SDN1
CRISPR/Cas

Southwest University
Yangtze University, China
University of Cologne, Germany
University of Maryland

Viral resistance: reduced viral accumulation and amelioration of virus-induced symptoms by Potato Virus Y.
(Lucioli et al., 2022)

SDN1
CRISPR/Cas

ENEA
Council for Agricultural Research and Economics (CREA), Italy
National Agricultural Research and Innovation Centre, Hungary

Fungal resistance: reduced susceptibility to Verticillium longisporum, a pathogen causing Verticillium stem striping. No fungicide treatments are currently available to control this disease.
(Pröbsting et al., 2020)

SDN1
CRISPR/Cas

Christian-Albrechts-University of Kiel
Institut für Zuckerrübenforschung
NPZ Innovation GmbH, Germany

Fungal resistance: resistance to Fusarium graminearum. Fusarium head blight (FHB) is an economically important disease, affecting both yield and grain quality of maize, wheat and barley.
(Brauer et al., 2020)

SDN1
CRISPR/Cas

Ottawa Research and Development Centre, Canada

Viral resistance: enhanced resistance against chickpea chlorotic dwarf virus (CpCDV). The range of symptoms caused by CpCDV varies from mosaic pattern to streaks to leaf curling and can include browning of the collar region and stunting, foliar chlorosis and necrosis.
(Munir Malik et al., 2022)

SDN1
CRISPR/Cas

University of the Punjab
University of Gujrat, Pakistan
Washington State University, USA

Fungal resistance: increased resistance to both biotrophic and necrotrophic plant pathogenic fungi, Bipolaris spot blotch and Fusarium root rot.
(Galli et al., 2022)

SDN1
CRISPR/Cas

Justus Liebig University, Germany

Viral resistance: reduced cotton leaf curl viral (CLCuV) load with asymptomatic plants. <br /> CLCuV causes a very devastating and prevalent disease. It causes huge losses to textile and other industries.
(Shakoor et al., 2023)

SDN1
CRISPR/Cas

University of the Punjab
University of Gujrat, Pakistan
Pacific Biosciences
CureVac Manufacturing GmbH, Germany

Viral resistance: to Cotton Leaf Curl Kokhran Virus, causing Cotton leaf curl disease (CLCuD), a very devastating and prevalent disease. CLCuD causes huge losses to the textile and other industries.
(Hamza et al., 2021)

SDN1
CRISPR/Cas

National Institute for Biotechnology and Genetic Engineering, Pakistan

Viral resistance: Resistance to Potato Virus Y (PVY), one of the most devastating viral pathogens causing substantial harvest losses.
(Zhan et al., 2019)

CRISPR/Cas

Hubei University
Huazhong Agricultural University, China
Max‐Planck‐Institut für Molekulare Pflanzenphysiologie, Germany

Broad-spectrum resistance against multiple Potato virus Y (PVY)-strains.
( Noureen et al., 2022 )

SDN1
CRISPR/Cas

Constituent College of Pakistan Institute of Engineering and Applied Sciences (PIEAS)
University Institute of Biochemistry and Biotechnology (UIBB), Pakistan

Bacterial resistance: Strong resistance to Xanthomonas oryzae, causing bacterial blight, a devastating rice disease resulting in yield losses.
(Xu et al., 2021)

SDN1
TALENs

Shanghai Jiao Tong University, China
Crop Diseases Research Institute, Pakistan

Fungal resistance: decreased susceptibility to Ustilago maydis, causing smut. The pathogen causes galls on all aerial parts of the plant, impacting crop yield and quality.
(Pathi et al., 2020)

SDN1
CRISPR/Cas

Leibniz Institute of Plant Genetics and Crop Plant Research, Germany

Fungal resistance: increased resistance to Phytophthora infestans, causing late blight disease, the most serious disease of potato crops worldwide. The pathogen can infect the leaves, stems and tubers of potato plants. An unprotected field can be completely destroyed in several days.
(Kieu et al., 2021)

SDN1
CRISPR/Cas

Swedish University of Agricultural Sciences, Sweden
University of Copenhagen, Denmark

Resistance against a protist pathogen: stable resistance against clubroot disease. Clubroot disease is caused by the protist Plasmodiophora brassicae Woronin and can result in a 10-15% yield loss in Brassica species as well as related crops.
(Hu et al., 2023)

SDN1
CRISPR/Cas

Saskatoon Research and Development Centre, Canada

Fungal resistance: improved sheath blight resistance. Sheath blight disease caused by Rhizoctonia solani AGI-1A and is one of the three major rice diseases. Sheath blight disease can cause severe yield losses.
(Cao et al., 2021)

SDN1
CRISPR/Cas

Agricultural College of Yangzhou University
Jiangsu Yanjiang Institute of Agricultural Science
Yangzhou University
Testing Center of Yangzhou University
Ministry of Agriculture
Chinese Academy of Agricultural Sciences
Institutes of Agricultural Science and Technology Development, China
BASF, Germany

Bacterial resistance: Strong resistance to Xanthomonas oryzae, causing bacterial blight, a devastating rice disease resulting in yield losses.
(Zafar et al., 2020)

SDN1
CRISPR/Cas

Constituent College of Pakistan Institute of Engineering and Applied Sciences
University of Information Technology
Engineering and Management Sciences
Constituent College of Pakistan Institute of Engineering and Applied Sciences, Pakistan

Viral resistance: Increased resistance to the barley mild mosaic virus (BaMMV), which can cause yield losses as high as 50% upon infection.
(Hoffie et al., 2022)

SDN1
CRISPR/Cas

Leibniz-Institute of Plant Genetics and Crop Plant Research (IPK)
Federal Research Centre for Cultivated Plants, Germany

Rapid detection of toxigenic Fusarium verticillioides, a phytopathogenic fungus that causes Fusarium ear and stalk rot and poses a threat to maize yields. This accurate and portable detection equipment has great potential for detection of the pathogen, even in areas lacking proper lab equipment.
( Liang et al., 2023 )

SDN1
CRISPR/Cas

Institute of Food Science and Technology
North Minzu University
School of Food Science and Engineering, China
Gembloux Agro-Bio Tech, Belgium

Viral resistance: increased resistance to chickpea chlorotic dwarf virus (CpCDV).
(Malik et al., 2023)

SDN1
CRISPR/Cas

University of the Punjab
University of Gujrat, Pakistan
Washington State University, USA

Fungal resistance: Reduced susceptibility to Verticillium longisporum, fungal pathogen that causes stem striping in Brassica napus and leads to huge yield losses.
(Ye et al., 2024)

SDN1
CRISPR/Cas

Christian-Albrechts-University of Kiel
Institut für Zuckerrübenforschung
Hohenlieth-Hof, NPZ Innovation GmbH, Germany
Aswan University, Egypt
Fujian Agriculture and Forestry University, China

Viral resistance: Highly efficient resistance against wheat dwarf virus (WDV), an economically important virus. WDV infect both wheat and barley causing severe yield losses. The natural resistance resources are limited.
(Kis et al., 2019)

SDN1
CRISPR/Cas

University of Pannonia
Hungarian Academy of Sciences
Eötvös Loránd University University
Szent István University, Hungary

Fungal resistance: resistance to Oidium neolycopersici, causing powdery mildew.
(Nekrasov et al., 2017)

SDN1
CRISPR/Cas

Max Planck Institute for Developmental Biology, Germany
Norwich Research Park, UK

Fungal resistance: Increased tolerance against Fusarium oxysporum f. sp. lycopersici, causing vascular wilt.
(Ijaz et al., 2022)

SDN1
CRISPR/Cas

University of Agriculture, Pakistan

Bacterial resistance: improved resistance to Xanthomonas oryzae, which causes bacterial blight, a devastating rice disease resulting in yield losses.
(Oliva et al., 2019)

SDN1
CRISPR/Cas

International Rice Research Institute, Philippines
University of Missouri
University of Florida
Iowa State University
Donald Danforth Plant Science Center, USA
Université Montpellier, France
Heinrich Heine Universität Düsseldorf
Max Planck Institute for Plant Breeding Research
Erfurt University of Applied Sciences, Germany
Nagoya University, Japan

Traits related to abiotic stress tolerance

Drought tolerance.
( Njuguna et al., 2018 )

SDN1
CRISPR/Cas

Ghent University
Center for Plant Systems Biology, Belgium
Jomo Kenyatta University of Agriculture and Technology, Kenya

Reduced cuticle permeability and enhanced drought tolerance.
( He et al., 2022 )

SDN1
CRISPR/Cas

Northwest A&
F University
USA
University of British Columbia, Canada

Traits related to improved food/feed quality

Improved seed oil content: increased levels of monounsaturated fatty acids and decreased levels of polyunsaturated fatty acids.
(Wang et al., 2022)

SDN1
CRISPR/Cas

Huazhong Agricultural University, China
National Research Council Canada, Canada

Improved cold storage and processing traits: lower levels of reduced sugars
(Yasmeen et al., 2022)

SDN1
CRISPR/Cas

University of the Punjab, Pakistan

Reduction of phytic acid (PA) in seeds. PA has adverse effects on essential mineral absorption and thus is considered as an anti-nutritive for monogastric animals.
( Sashidhar et al., 2020 )

SDN1
CRISPR/Cas

Christian-Albrechts-University of Kiel
Max-Planck-Institute for Evolutionary Biology, Germany

Removing the major allergen to tackle food allergies.
( Assou et al., 2021 )

SDN1
CRISPR/Cas

Leibniz Universität Hannover
Technische Universität Braunschweig, Germany

Reduced glucosinolate levels. Glucosinolates are anti-nutrients that can cause reduced performance and impairment of kidney and liver functions of livestock.
( Hölzl et al., 2022 )

SDN1
CRISPR/Cas

University of Bonn
Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Germany

Reduce malnutrition by decreasing antinutrient phytic acid (PA) and increasing Iron and Zinc accumulation. PA has adverse effects on essential mineral absorption and thus is considered as an anti-nutritive for monogastric animals.
( Ibrahim et al., 2021 )

SDN1
CRISPR/Cas

Quaid-i-Azam University Islamabad
National Agricultural Research Centre, Pakistan

Modified composition: accumulation of fivefold more starch than WT leaves, and more sucrose as well. Architectural changes
(Bezrutczyk et al., 2018)

SDN1
CRISPR/Cas

Heinrich Heine University Düsseldorf
Max Planck Institute for Plant Breeding Research, Germany
Department of Plant Biology, Carnegie Science, USA

Altered protein composition due to mutations in seed storage proteins. Two major families of storage proteins, account for about 70% of total soy seed protein. Some major biochemical components influencing the quality of soy food products, for example tofu, are both the quantity and quality of storage proteins in soybean seeds.
( Li et al., 2019 )

SDN1
CRISPR/Cas

Agriculture and Agri-Food Canada
Western University
Harrow Research and Development Centre, Canada
Sun Yat-sen University
Guangdong Academy of Agricultural Sciences
Minnan Normal University
China

Reduces phytic acid (anti-nutrient) and improves iron and zinc accumulation in wheat grains. Biofortification.
( Ibrahim et al., 2021 )

SDN1
CRISPR/Cas

Quaid-i-Azam University Islamabad
National Agricultural Research Centre, Pakistan

Glossy sheat phenotype.
( Gerasimova et al., 2023 )

SDN1
CRISPR/Cas

Siberian Branch of the Russian Academy of Sciences
Vavilov Institute of Plant Genetic Resources (VIR)
Siberian Branch of the Russian Academy of Sciences, Russia

Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Germany

Increased amylose content. Cereals high in amylose content (AC) and resistant starch (RS) offer potential health benefits and reduce risks of diseases such as coronary heart disease, diabetes and certain colon and rectum cancers.
( Sun et al., 2017 )

SDN1
CRISPR/Cas

Chinese Academy of Agricultural Sciences, China
University of California, USA
University of Liege, Belgium

Traits related to increased plant yield and growth

Increased yield: plants produced more tillers and grains than azygous wild-type controls and the total yield was increased up to 15 per cent.
(Holubova et al., 2018)

SDN1
CRISPR/Cas

Palacký University
Centre of the Region Haná for Biotechnological and Agricultural Research, Czech Republic
Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Germany

Combine agronomically desirable traits with useful traits present in wild lines. Threefold increase in fruit size and a tenfold increase in fruit number. Fruit lycopene accumulation is improved by 500% compared with the widely cultivated S. lycopersicum.
( Zsögön et al., 2018 )

SDN1
CRISPR/Cas

Universidade Federal de Viçosa
Universidade de São Paulo Paulo, Brazil
University of Minnesota, USA
Universität Münster, Germany

Increased seed oil content (SOC). SOC is a major determinant of yield and quality.
( Karunarathna et al., 2020 )

SDN1
CRISPR/Cas

Christian-Albrechts-University of Kiel, Germany
Zhejiang University, China

Increased tiller number.
( Awan et al., 2024 )

SDN1
CRISPR/Cas

National Institute for Biotechnology and Genetic Engineering
Quaid-i-Azam University, Pakistan

Control meristem size to increase fruit yield.
( Yuste-Lisbona et al., 2020 )

SDN1
CRISPR/Cas

Universidad de Almería
Universitat Politècnica de València–Consejo Superior de Investigaciones Científicas
Spain
Max Planck Institute for Plant Breeding Research
Thünen Institute of Forest Genetics, Germany
Université Paris-Saclay, France

Increased water use efficiency without growth reductions in well-watered conditions.
( Blankenagel et al., 2022 )

SDN1
CRISPR/Cas

Technical University of Munich
Max Planck Institute of Molecular Plant Physiology
German Research Center for Environmental Health
KWS SAAT SE &
Co.KGaA
Université Technique de Munich
Heinrich Heine University, Germany
LEPSE - Écophysiologie des Plantes sous Stress environnementaux, France

Confer shoot architectural changes for increased resource inputs to increase crop yield.
( Stanic et al., 2021 )

SDN1
CRISPR/Cas

University of Calgary, Canada
SRM Institute of Technology, India

Improves complex traits such as yield and drought tolerance.
( Lorenzo et al., 2022 )

SDN1
CRISPR/Cas

Center for Plant Systems Biology
Ghent University
Flanders Research Institute for Agriculture Fisheries and Food (ILVO), Belgium

Altered root architecture with increased tillers and total grain weight.
( Rahim et al., 2023 )

SDN1
CRISPR/Cas

Quaid-e-Azam University
National Agricultural Research Centre (NARC)
The University of Haripur, Pakistan
King Saud University, Saudi Arabia
Nile University
Ain Shams University, Egypt
Chonnam National University, South Korea

Early flowering. Day-light sensitivity limited the geographical range of cultivation.
( Soyk et al., 2016 )

SDN1
CRISPR/Cas

Cold Spring Harbor Laboratory, USA
Max Planck Institute for Plant Breeding Research, Germany
Université Paris-Scalay, France

Altered spike architecture.
( de Souza Moraes et al., 2022 )

SDN1
CRISPR/Cas

Wageningen University and Research, The Netherlands
Universidade de São Paulo, Brazil
Norwich Research Park, UK
Rheinische Friedrich-Wilhelms-Universität, Germany

Root growth angle regulation, among the most important determinants of root system architecture. Root growth angle controls water uptake capacity, stress resilience, nutrient use efficiency and thus yield of crop plants.
( Kirschner et al., 2021 )

SDN1
CRISPR/Cas

University of Bonn
University of Cologne
Leibniz Institute of Plant Genetics and Crop Plant Research Gatersleben
Justus-Liebig-University Giessen, Germany
University of Bologna, Italy

Production of enlarged, dome-shaped leaves. Enlarged fruits with increased pericarp thickness due to cell expansion.
( Swinnen et al., 2022 )

SDN1
CRISPR/Cas

Ghent University
Center for Plant Systems Biology, Vives, Belgium
Université de Bordeaux, France

Control grain size and seed coat color.
( Tra et al., 2021 )

International Rice Research Institute, Philippines
Dahlem Center of Plant Sciences Freie UniversitÃ¤t, Germany
Synthetic Biology, Biofuel and Genome Editing R&
D Reliance Industries Ltd, India

Increased water use efficiency, a promising approach for achieving sustainable crop production in changing climate scenarios.
( Blankenagel et al., 2022 )

SDN1
CRISPR/Cas

Technical University of Munich
Max Planck Institute of Molecular Plant Physiology
Helmholtz Center Munich
Heinrich Heine University Düsseldorf, Germany

Induced erect leaf habit and shoot growth for a more efficient light penetration into lower canopy layers.
( Fladung et al., 2021 )

SDN1
CRISPR/Cas

Thünen Institute of Forest Genetics, Germany

Increase in 1000-grain weight, grain area, grain width, grain length, plant height, and spikelets per spike.
( Errum et al., 2023 )

SDN1
CRISPR/Cas

National Agricultural Research Centre (NARC)
PARC Institute of Advanced Studies in Agriculture (PIASA)
Pakistan Agricultural Research Council, Pakistan

Increased shatter resistance to avoid seed loss during mechanical harvest.
( Braatz et al., 2017 )

SDN1
CRISPR/Cas

Christian-Albrechts-University of Kiel, Germany

Traits related to industrial utilization

Reduced lignin content and increased sugar release upon saccharification.
( De Meester et al., 2021 )

SDN1
CRISPR/Cas

Ghent University
VIB Center for Plant Systems Biology, Belgium

35% reduction in lignin. Fourfold increase in cellulose-to-glucose conversion upon limited saccharification. Efficient saccharification is hindered by the presence of lignin in the secondary-thickened cell walls.
( de Vries et al., 2021 )

SDN1
CRISPR/Cas

Ghent University
VIB Center for Plant Systems Biology, Belgium

Manipulation of self-incompatibility.
( Zhang et al., 2020 )

SDN1
CRISPR/Cas

Chinese Academy of Sciences, China
Aarhus University
DLF Seeds A/S, Denmark

Nicotine-free tobacco.
( Schachtsiek et al., 2019 )

SDN1
CRISPR/Cas

TU Dortmund University, Germany

Glycoproteins without plant-specific glycans. Plants or plant cells can be used to produce pharmacological glycoproteins, for example antibodies or vaccines. However these proteins carry N-glycans with plant-typical residues [β(1,2)-xylose and core α(1,3)-fucose]. This plant-specific glycans can greatly impact the immunogenicity, allergenicity, or activity of the protein.
( Mercx et al., 2017 )

SDN1
CRISPR/Cas

Université catholique de Louvain
Université de Liège, Belgium

Early heading: in regions with short growing seasons, early maturing varieties to escape frost damage are required.
(Sohail et al., 2022)

SDN1
CRISPR/Cas

China National Rice Research Institute
Northern Center of China National Rice Research Institute
Zhejiang A&
F University, China
Mir Chakar Khan Rind University
Agriculture Research System Khyber, Pakistan
Ministry of Agriculture, Bangladesh
Agriculture Research Center, Egypt

Jointless tomatoes. Pedicel abscission is an important agronomic factor that controls yield and post-harvest fruit quality. In tomato, floral stems that remain attached to harvested fruits during picking mechanically damage the fruits during transportation, decreasing the fruit quality for fresh-market tomatoes and the pulp quality for processing tomatoes.
( Roldan et al., 2017 )

SDN1
CRISPR/Cas

Institute of Plant Sciences Paris-Saclay (IPS2), France
University of Liège, Belgium

Tailoring poplar lignin without yield penalty. Reduced recalcitrance.
( De Meester et al., 2020 )

SDN1
CRISPR/Cas

Ghent University
VIB Center for Plant Systems Biology
VIB Metabolomics Core, Belgium

Doubled haploids with increased leaf size. Doubled haploid technology is used to obtain homozygous lines in a single generation. This technique significantly accelerates the crop breeding trajectory.
( Impens et al., 2023 )

SDN1
CRISPR/Cas

Ghent University
VIB-UGent Center for Plant Systems Biology
Flanders Research Institute for Agriculture, Fisheries and Food (ILVO), Belgium

Traits related to herbicide tolerance

Glyphosate & hppd inhibitor herbicides, for example tembotrione
( D'Halluin et al., 2013 )

SDN2
CRISPR/Cas

Bayer CropScience N.V, Belgium

Herbicide tolerance: Bispyribac-sodium (BS). BS is a pyrimidinyl carboxy herbicide.
(Zafar et al., 2023)

SDN2
CRISPR/Cas

Constituent College of Pakistan Institute of Engineering and Applied Sciences
Engineering and Management Sciences (BUITEMS), Pakistan

Herbicide tolerance: AHAS-inhibiting
(Gocal et al., 2015)

ODM

Cibus, Canada
Cibus, USA

Traits related to product color/flavour

Colour shift. The poinsettia belongs to most economically important potted ornamental plants. Customers are willing to pay higher prices for unusual varieties.
( Nitarska et al., 2021 )

SDN1
CRISPR/Cas

Technische Universität Wien, Austria
Klemm+Sohn GmbH &
Co
Leibniz Universität Hannover, Germany

A significant reduction of saponins. Saponins are a source of bitter, and metallic off-flavors in products containing peas.
( Hodgins et al., 2024 )

SDN1
CRISPR/Cas

Universityof Calgary
Universityof Saskatchewan
National Research Council of Canada, Canada

Albino phenotype
( Bánfalvi et al., 2020 )

SDN1
CRISPR/Cas

NARIC Agricultural Biotechnology Institute, Hungary

Increased content of phenylacetaldehyde, sucrose and fructose, which are major contributors to flavor in many foods, including tomato.
( Li et al., 2023 )

SDN1
CRISPR/Cas

University of Florida, USA
Max-Planck-Institute of Molecular Plant Physiology, Germany

Improved aroma, flavour and fatty acid (FA) profiles of pea seeds.
( Bhowmik et al., 2023 )

SDN1
CRISPR/Cas

National Research Council Canada (NRC)
University of Calgary
University of Saskatchewan
Agriculture and Agri-Food Canada (AAFC)
St. Boniface Hospital Research, Canada
John Innes Centre, UK

Traits categories

Genome Editing Technique

Countries

Plant

Sdn Type

Traits related to biotic stress tolerance

Traits related to abiotic stress tolerance

Traits related to improved food/feed quality

Traits related to increased plant yield and growth

Traits related to industrial utilization

Traits related to herbicide tolerance

Traits related to product color/flavour