genome search | EU-SAGE

Genome-editing techniques are promising tools in plant breeding. To facilitate a more comprehensive understanding of the use of genome editing, EU-SAGE developed an interactive, publicly accessible online database of genome-edited crop plants as described in peer-reviewed scientific publications.
The aim of the database is to inform interested stakeholder communities in a transparent manner about the latest evidence about the use of genome editing in crop plants. Different elements including the plant species, traits, techniques, and applications can be filtered in this database.
Regarding the methodology, a literature search in the bibliographic databases and web pages of governmental agencies was conducted using predefined queries in English. Identifying research articles in other languages was not possible due to language barriers. Patents were not screened.
Peer-reviewed articles were screened for relevance and were included in the database based on pre-defined criteria. The main criterium is that the research article should describe a research study of any crop plant in which a trait has been introduced that is relevant from an agricultural and/or food/feed perspective. The database does neither give information on the stage of development of the crop plant, nor on the existence of the intention to develop the described crop plants to be marketed.
This database will be regularly updated. Please contact us via the following webpage in case you would like to inform us about a new scientific study of crops developed for market-oriented agricultural production as a result of genome editing

Displaying 69 results

Traits related to biotic stress tolerance

Increased basal immunity and broad spectrum disease resistance.
( Leibman-Markus et al., 2023 )

SDN1
CRISPR/Cas

Volcani Institute
Tel Aviv University, Israel

Viral resistance: improved resistance against a tobamovirus, which could threaten tomato, tobacco, potato and squash plants.
(Miyoshi et al., 2024)

SDN1
CRISPR/Cas

Ehime University
Ehime Research Institute of Agriculture, Japan

Virus resistance: Immunity to cucumber vein yellowing virus infection (Ipomovirus) and resistance to the potyviruses Zucchini yellow mosaic virus and Papaya ring spot mosaic virus.
(Chandrasekaran et al., 2016)

SDN1
CRISPR/Cas

Volcani Center, Israel

Bacterial resistance: improved resistance to Xanthomonas oryzae, which causes bacterial blight, a devastating rice disease resulting in yield losses.
(Oliva et al., 2019)

SDN1
CRISPR/Cas

International Rice Research Institute, Philippines
University of Missouri
University of Florida
Iowa State University
Donald Danforth Plant Science Center, USA
Université Montpellier, France
Heinrich Heine Universität Düsseldorf
Max Planck Institute for Plant Breeding Research
Erfurt University of Applied Sciences, Germany
Nagoya University, Japan

Resistance to parasitic weed: Phelipanche aegyptiaca. The obligate root parasitic plant causes great damages to important crops and represents one of the most destructive and greatest challenges for the agricultural economy.
(Bari et al., 2021)

SDN1
CRISPR/Cas

Central University of Punjab, India
Newe Ya’ar Research Center
Agricultural Research Organization (ARO), Israel

Viral resistance: increased resistance to infection with the potato virus Y (PVY) and tolerance to salt and osmotic stress. PVY is one of the most economically important potato pathogens
(Makhotenko et al., 2019)

SDN1
CRISPR/Cas

Russia Moscow State University, Russia
Doka Gene Technologies Ltd, USA

Viral resistance: Resistance to Tomato brown rugose fruit virus (ToBRFV), a major threat to the production of tomato.
(Ishikawa et al., 2022)

SDN1
CRISPR/Cas

Institute of Agrobiological Sciences
Takii and Company Limited, Japan

Viral resistance: resistance to potyvirus potato virus Y (PVY), which causes serious yield loss.
(Kumar et al., 2022)

SDN1
CRISPR/Cas

Agricultural Research Organization, Israel

Fungal resistance: Reduced susceptibility to necrotrophic fungi. Necrotrophic fungi, such as Botrytis cinerea and Alternaria solani, cause severe damage in tomato production.
(Ramirez Gaona et al., 2023)

SDN1
CRISPR/Cas

Wageningen University &
Research, The Netherlands
Takii &
Company Limited, Japan

High resistance to powdery mildew under semi-commercial growth conditions.
( Shnaider et al., 2022 )

SDN1
CRISPR/Cas

Agricultural Research Organization Volcani Center, Israel

Nematode resistance: decreased susceptibility against root-knot nematodes, showing fewer gall and egg masses.
(Noureddine et al., 2023)

SDN1
CRISPR/Cas

Université Côte d’Azur
Université de Toulouse, France
Kumamoto University, Japan

Viral resistance: partial resistance to Pepper veinal mottle virus (PVMV) isolate IC, with plants harboring weak symptoms and low virus loads at the systemic level.
(Moury et al., 2020)

SDN1
CRISPR/Cas

INRA, France
Université de Tunis El-Manar
Université de Carthage, Tunisia
Université Felix Houphouët-Boigny, Cote d’Ivoire
Institut de l’Environnement et de Recherches Agricoles, Burkina Faso

SDN1
CRISPR/Cas

Newe Ya’ar Research Center,
Agricultural Research Organization (ARO), Israel
University of California, USA

Traits related to abiotic stress tolerance

Enhanced responses to abscisic acid (ABA), which plays an important role in drought stress responses in plants. Improved drought tolerance through stomatal regulation and increased primary root growth under non-stressed conditions.
( Ogata et al., 2020 )

SDN1
CRISPR/Cas

Japan International Research Center for Agricultural Sciences (JIRCAS)
RIKEN Center for Sustainable Resource Science
University of Tsukuba, Japan

Increased tolerance to cold stress.
( Teper-Bamnolker et al., 2022 )

SDN1
CRISPR/Cas

The Volcani Institute
The Hebrew University of Jerusalem
Danziger Innovations Limited, Israel

Altered cuticle properties to enhance drought tolerance.
( Negin et al., 2021 )

SDN1
CRISPR/Cas

Weizmann Institute of Science, Israel

Improved lodging resistance.
( Wakasa et al., 2024 )

SDN1
CRISPR/Cas

Institute of Agrobiological Sciences
Institute of Crop Sciences, Japan

Increased salt-tolerance.
( Antonova et al., 2024 )

SDN1
CRISPR/Cas

Institute of Plant and Animal Ecology (IPAE)
N.I. Vavilov All-Russian Institute of Plant Genetic Resources (VIR)
Institute of Cytology and Genetics (ICG), Russia

Increased drought tolerance: suppresses xylem vessel proliferation, leading to lower water conductance, and reduced water-loss under water-deficit conditions.
(Illouz-Eliaz et al., 2020)

SDN1
CRISPR/Cas

Institute of Plant Sciences and Genetics in Agriculture
The Robert H. Smith Faculty of Agriculture
The Hebrew University of Jerusalem, Israel

Increased root length, which can restore good performance under water stress.
( Gabay et al., 2023 )

SDN1
CRISPR/Cas

University of California
Howard Hughes Medical Institute, USA
University of Haifa, Israel
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
Universidad Nacional de San Martín (UNSAM), Argentina
Fudan University
China Agricultural University, China
Karolinska Institutet, Sweden

Increased tolerance to salinity stress. Improved rice yields in saline paddy fields by root angle modifications to adapt to climate change.
( Kitomi et al., 2020 )

SDN1
CRISPR/Cas

National Agriculture and Food Research Organization (NARO)
Tohoku University
Institute of Agrobiological Sciences
Japan Science and Technology Agency (JST)
Advanced Analysis Center
National Institute of Advanced Industrial Science and Technology (AIST), Japan

Traits related to improved food/feed quality

Increased NH4+ and PO43− uptake, and photosynthetic activity under high CO2 conditions in rice. Largely increased panicle weight. Improved grain appearance quality or a decrease in the number of chalky grains.
( Iwamoto et al., 2022 )

SDN1
CRISPR/Cas

Institute of Agrobiological Sciences, Japan

Improved kafirin digestibility, which increases the grain nutritional value.
( Elkonin et al., 2023 )

SDN1
CRISPR/Cas

Federal Centre of Agriculture Research of South-East Region
Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, Russia

Complete abolition of glycoalkaloids, causing a bitter taste and toxic to various organisms.
( Nakayasu et al., 2018 )

SDN1
CRISPR/Cas

Kobe University, Japan

Parthenocarpy: seedless tomato. Industrial purposes and direct eating quality.
(Klap et al., 2016)

SDN1
CRISPR/Cas

Agricultural Research Organization, Israel

Increased flavonoid content, functioning as allelochemicals and insect deterrents.
( Lam et al., 2019 )

SDN1
CRISPR/Cas

The University of Hong Kong
The Chinese University of Hong Kong
Shenzhen
Zhejiang Academy of Agricultural Sciences
Nanjing Forestry University, China
Kyoto University, Japan

Negligible levels of the possibly toxic steroidal glykoalkaloids (SGAs), but enhanced levels of steroidal saponins, which has pharmaceutically useful functions.
( Akiyama et al., 2017 )

SDN1
CRISPR/Cas

Kobe University
Riken Center for Sustainable Resource Science
Osaka University, Japan

Reduction of harmful ingredients: toxic steroidal glycoalkaloids (SGAs).
(Sawai et al., 2014)

SDN1
TALENs

RIKEN Center for Sustainable Resource Science
Chiba University, Japan

Glossy sheat phenotype.
( Gerasimova et al., 2023 )

SDN1
CRISPR/Cas

Siberian Branch of the Russian Academy of Sciences
Vavilov Institute of Plant Genetic Resources (VIR)
Siberian Branch of the Russian Academy of Sciences, Russia

Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Germany

High gamma-aminobutyric acid (GABA) content. GABA plays a key role in plant stress responses, growth, development and as a nutritional component of grain can also reduce the likelihood of hypertension and diabetes. Increased amino acid content. Higher seed weight and seed protein content.
( Akama et al., 2020 )

SDN1
CRISPR/Cas

Shimane University
Institute of Agrobiological Sciences
National Agriculture and Food Research Organization
Yokohama City University, Japan

Increased gamma-Aminobutyric acid (GABA) accumulation by 7 to 15 fold while having variable effects on plant and fruit size and yield. GABA is a nonproteogenic amino acid and has health-promoting functions.
( Nonaka et al., 2017 )

SDN1
CRISPR/Cas

University of Tsukuba, Japan

Seedless tomatoes for industrial purposes and direct eating quality.
( Ueta et al., 2017 )

SDN1
CRISPR/Cas

Tokushima University, Japan

Reduced steroidal glycoalkaloids.
( Yasumoto et al., 2019 )

TALENs

Osaka University
RIKEN Center for Sustainable Resource Science
Kobe University, Japan

Carotenoid accumulation to solve the problem of vitamin A deficiency that is prevalent in developing countries.
( Endo et al., 2019 )

SDN1
CRISPR/Cas

National Agriculture and Food Research Organization
Ishikawa Prefectural University, Japan

Increased carotenoid, lycopene, and β-carotene.
( Hunziker et al., 2020 )

University of Tsukuba
Kobe University
Institute of Vegetable and Floricultural Science
NARO, Japan

High-quality sugar production by rice (98% sucrose content). Carbohydrates are an essential energy-source. Sugarcane and sugar beet were the only two crop plants used to produce sugar.
( Honma et al., 2020 )

SDN1
CRISPR/Cas

Fujian Agriculture and Forestry University, China
Faculty of Engineering
Kitami Institute of Technology
NagoyaUniversity
Tokyo Metropolitan University, Japan
Carnegie Institution for Science, USA

Increased sugar content without decreased fruit weight. Sugar content is one of the most important quality traits of tomato.
( Kawaguchi et al., 2021 )

SDN1
CRISPR/Cas

Nagoya University
Kobe University
RIKEN Center for Sustainable Resource Science
University of Tsukuba, Japan

Improved digestibility of kafirins, which increases the grain nutritional value.
( Elkonin et al., 2023 )

SDN1
CRISPR/Cas

Federal Centre of Agriculture Research of South-East Region
Institute of Biochemistry and Genetics, Russia

Altered fatty acid composition. High oleic/low linoleic acid rice. Oleic acid has potential health benefits and helps decrease lifestyle disease.
( Abe et al., 2018 )

SDN1
CRISPR/Cas

National Agriculture and Food Research Organization, Japan

Improved fatty acid composition. The content and abundance of fatty acids play an important role in nutritional and processing applications of oilseeds.
( Okuzaki et al., 2018 )

SDN1
CRISPR/Cas

Tamagawa University
Osaka Prefecture University
Tamagawa University, Japan

Traits related to increased plant yield and growth

Improved nitrogen use efficiency, growth and yield in low nitrogen environment.
( Liu et al., 2023 )

SDN1
CRISPR/Cas

The University of Tokyo, Japan

Range of beneficial phenotypes: additional tillers and smaller culms and panicles.
(Cui et al., 2020)

SDN1
CRISPR/Cas

China National Rice Research Institute
Huazhong Agricultural University, China
Yangzhou University, Nagoya University, Japan

Transformation of a climbing woody perennial, developing axillary inflorescences after many years of juvenility, into a compact plant with rapid terminal flower and fruit development.
( Varkonyi-Gasic et al., 2022 )

SDN1
CRISPR/Cas

The New Zealand Institute for Plant &
Food Research Limited (Plant &
Food Research), University of Auckland, New Zealand

Regulating fruit ripening, one of the most important concerns in the study of fleshy fruit species.
( Ito et al., 2015 )

SDN1
CRISPR/Cas

National Food Research Institute, Japan

Reduction of plant height through accumulation of ceramides. Plant height is an important agronomic trait of rice, it directly affects the yield potential and lodging resistance.
( Wang et al., 2023 )

SDN1
CRISPR/Cas

Nanchang University
Henan Agricultural University, China
Hokkaido University, Japan

Increased grain yield under phosphorus-deficient conditions.
( Ishizaki et al., 2022 )

SDN1
CRISPR/Cas

Japan International Research Center for Agricultural Sciences (JIRCAS), Japan

Customize tomato cultivars for urban agriculture: increased compactness and decreased growth cycle of tomato plants.
(Kwon et al., 2020)

SDN1
CRISPR/Cas

Cold Spring Harbor Laboratory
Cornell University
University of Florida, USA
Wonkwang University, South Korea
Weizmann Institute of Science, Israel

Increased tiller number and grain yield.
( Cui et al., 2023 )

SDN1
CRISPR/Cas

The University of Tokyo
Kyoto University
National Institute of Crop Science, Japan

Elongated, occasionally peanut-like shaped fruit.
( Zheng et al., 2022 )

SDN1
CRISPR/Cas

Nagoya University
Kanazawa University, Japan
Huazhong Agricultural University, China

Plant development. Phenotypes consistent with increased GA response: tall and slender with light green vegetation.
(Lor et al., 2014)

SDN1
TALENs

University of Minnesota, USA
Hebrew University of Jerusalem, Israel

Altered plant architecture to inrease yield: increased node number on the main stem and branch number.
(Bao et al., 2019)

SDN1
CRISPR/Cas

Chinese Academy of Agricultural Sciences
Huazhong Agricultural University, China
Duy Tan University, Vietnam
RIKEN Center for Sustainable Resource Science, Japan

Traits related to industrial utilization

Restoring cytoplasmic sterility.
( Kazama et al., 2019 )

SDN2
TALENs

Tohoku University
Tamagawa University
The University of Tokyo
National Institute of Genetics
Tokyo Institute of Technology
Tamagawa University
Japan Science and Technology Agency, Japan

Significantly longer seed dormancy period, may result in reduced pre-harvest sprouting of grains on spikes.
( Abe et al., 2019 )

SDN1
CRISPR/Cas

Institute of Crop Science
Okayama University
Yokohama City University
Institute of Agrobiological Sciences
Obihiro University of Agriculture and Veterinary Medicine, Japan

Dwarf plants that retain favourable fruit traits.
( Nagamine et al., 2024 )

SDN1
CRISPR/Cas

University of Tsukuba, Japan

Production of herbicide-sensitive strain to prevent volunteer infestation. Volunteer rice grows when cultivated rice seed fall into fields, overwinter and spontaneously germinate the next spring.
( Komatsu et al., 2020 )

Institute of Agrobiological Sciences
National Agriculture and Food Research Organization (NARO)
Graduate School of Science
Technology and Innovation, Japan

Fertility restoration of cytoplasmic male sterility.
( Suketomo et al., 2020 )

SDN1
CRISPR/Cas

Tohoku University, Japan

Confer male and female sterility to prevent the risk of trasgene flow from transgenic plants to their wild relatives.
( Shinoyama et al., 2020 )

SDN1
TALENs

Fukui Agricultural Experiment Station
Institute of Agrobiological Sciences
National Agriculture and Food Research Organization (NARO)
Japan Science and Technology Agency (JST)
Yokohama City University, Japan
Altai State University, Russia

Conversion of hulled into naked barley.
( Gasparis et al., 2018 )

SDN1
CRISPR/Cas

National Research Institute
Warsaw University of Life Sciences (SGGW), Poland

Traits related to herbicide tolerance

Imazamox
( Shimatani et al. 2017 )

Kobe University
University of Tsukuba
Meijo University, Japan

Herbicide resistance
( Shimatani et al. 2018 )

Kobe University, Japan
University of Tsukuba, Japan

Herbicide tolerance: ALS-inhibiting
(Okuzaki et al., 2004)

ODM

Tohoku University, Japan

Resistance to ALS-inhibiting herbicides.
( Okuzaki et al., 2003 )

ODM

Tohoku University, Japan

Traits related to product color/flavour

Flower color modification due to reduced anthocyanin content. Flower color is one of the most important traits in ornamental flowers.
( Nishihara et al. (2018) )

SDN1
CRISPR/Cas

Iwate Biotechnology Research Center, Japan

Reduced citrate content. Citrate is a common primary metabolite which often characterizes fruit flavour.
( Fu et al., 2023 )

SDN1
CRISPR/Cas

Zhejiang University, China
University of Florida, USA
The New Zealand Institute for Plant &
Food Research Limited (Plant &
Food Research) Mt Albert
University of Auckland, New Zealand

Yellow and orange fruit color.
( Dahan-Meir et al., 2018 )

SDN2
CRISPR/Cas

Weizmann Institute of Science, Israel

Color modification: yellow. Ipomoea nil exhibits a variety of flower colours, except yellow.
(Watanabe et al., 2018)

SDN1
CRISPR/Cas

University of Tsukuba
National Agriculture and Food Research Organization, Japan

Fruit color: tangerine
(Ben Shlush et al., 2021)

SDN2
CRISPR/Cas

The Weizmann Institute of Science, Israel

Color modification due to reduced anthocyanin accumulation.
( Klimek-Chodacka et al., 2018 )

SDN1
CRISPR/Cas

University of Agriculture in Krakow, Poland
East Carolina University
University of Maryland, USA

Traits related to storage performance

The fruit remains green and shows higher firmness as well as no early fermentation. This results in extended shelf-life which could reduce food loss and contribute to food security.
( Nonaka et al., 2023 )

SDN1
CRISPR/Cas

University of Tsukuba, Japan

Traits categories

Genome Editing Technique

Countries

Plant

Sdn Type

Traits related to biotic stress tolerance

Traits related to abiotic stress tolerance

Traits related to improved food/feed quality

Traits related to increased plant yield and growth

Traits related to industrial utilization

Traits related to herbicide tolerance

Traits related to product color/flavour

Traits related to storage performance