genome search | EU-SAGE

Genome-editing techniques are promising tools in plant breeding. To facilitate a more comprehensive understanding of the use of genome editing, EU-SAGE developed an interactive, publicly accessible online database of genome-edited crop plants as described in peer-reviewed scientific publications.
The aim of the database is to inform interested stakeholder communities in a transparent manner about the latest evidence about the use of genome editing in crop plants. Different elements including the plant species, traits, techniques, and applications can be filtered in this database.
Regarding the methodology, a literature search in the bibliographic databases and web pages of governmental agencies was conducted using predefined queries in English. Identifying research articles in other languages was not possible due to language barriers. Patents were not screened.
Peer-reviewed articles were screened for relevance and were included in the database based on pre-defined criteria. The main criterium is that the research article should describe a research study of any crop plant in which a trait has been introduced that is relevant from an agricultural and/or food/feed perspective. The database does neither give information on the stage of development of the crop plant, nor on the existence of the intention to develop the described crop plants to be marketed.
This database will be regularly updated. Please contact us via the following webpage in case you would like to inform us about a new scientific study of crops developed for market-oriented agricultural production as a result of genome editing

Displaying 45 results

Traits related to biotic stress tolerance

Increased resistance to drought stress by enhancing antioxidant capacity and defence system.
( Gao et al., 2022 )

SDN1
CRISPR/Cas

Henan Agricultural University
China Tobacco Sichuan Industrial Co., China

Viral resistance: enhanced Potato virus Y (PVY) resistance. PVY infection can result in up to 70% yield loss globally.
(Le et al., 2022)

SDN1
CRISPR/Cas

Vietnam Academy of Science and Technology, Vietnam
University of Edinburgh, UK

Enhanced resistance to powdery mildew.
( Wang et al., 2022 )

SDN1
CRISPR/Cas

Chinese Academy of Agricultural Sciences Institute of Tobacco Research, China

Viral resistance: highly resistant to viral infection with beet severe curly top virus (BSCTV), a geminivirus that can cause serious damage to many crop plants.
(Ji et al., 2015)

SDN1
CRISPR/Cas

University of Chinese Academy of Sciences, China

Viral resistance: Attenuated infection symptoms and reduced viral RNA accumulation, specific for the cucumber mosaic virus (CMV) or tobacco mosaic virus (TMV).
(Zhang et al., 2018)

SDN1
CRISPR/Cas

South China Agricultural University, China
University of Missouri, USA

Visualization of the early stages of Cassava bacterial blight (CBB) infection in vivo. CBB is caused by Xanthomonas axonopodis pv. Manihotis.
( Veley et al., 2021 )

SDN2
CRISPR/Cas

Donald Danforth Plant Science Center, USA
National Root Crops Research Institute, Nigeria

Viral resistance: reduced cassava brown streak disease (CBSD) symptom severity and incidence. CBSD threatens cassava production in West Africa and is a major constraint on cassava production in East and Central Africa.
(Gomez et al., 2019)

SDN1
CRISPR/Cas

University of California
Donald Danforth Plant Science Center, USA

Viral resistance: resistance to potato virus Y (PVY), one of the most economically and scientifically important plant viruses, causing damaging diseases of cultivated tobacco around the world.
(Ruyi et al., 2021)

SDN1
CRISPR/Cas

Mudanjiang Teachers College
Jilin Normal University
Mudanjiang Tobacco Research Institute, China

Viral resistance: to Cotton Leaf Curl Kokhran Virus, causing Cotton leaf curl disease (CLCuD), a very devastating and prevalent disease. CLCuD causes huge losses to the textile and other industries.
(Hamza et al., 2021)

SDN1
CRISPR/Cas

National Institute for Biotechnology and Genetic Engineering, Pakistan

Viral resistance: increased resistance against Tobacco Mosaic Virus (TMV).
(Jogam et al., 2023)

SDN1
CRISPR/Cas

Kakatiya University
Center of Innovative and Applied Bioprocessing (DBT-CIAB), India
University of Minnesota
East Carolina University, USA

Fungal resistance: enhanced resistance to Golovinomyces cichoracearum, which causes powdery mildew.
(Wang et al., 2023)

SDN1
CRISPR/Cas

Chinese Academy of Agricultural Sciences
Linyi Tobacco Company
Tobacco Research Institute of Hubei Province
China Tobacco Hunan Industrial Co., China

Rapid detection of Sclerotium rolfsii, the causal agent of stem and root rot disease. This technique is effective for identification of pathogens, with potential for on-site testing.
( Changtor et al., 2023 )

SDN1
CRISPR/Cas

Naresuan University, Thailand

Viral resistance: improved resistance against a tobamovirus, which could threaten tomato, tobacco, potato and squash plants.
(Miyoshi et al., 2024)

SDN1
CRISPR/Cas

Ehime University
Ehime Research Institute of Agriculture, Japan

Traits related to abiotic stress tolerance

Improved Cadmium (Cd)-tolerance by reducing the Cd transport from vacuole to cytosol in tobacco leaves.
( Jia et al., 2022 )

SDN1
CRISPR/Cas

Henan Agricultural University
Xiamen University, China

Increased drought tolerance.
( Xu et al., 2023 )

SDN1
CRISPR/Cas

R&
D Center of China Tobacco Yunnan Industrial Co. Ltd.
Sichuan Agriculture University, China

Enhanced resistance to drought stress with increased osmotic adjustment, antioxidant activity, photosynthetic efficiency and decreased water loss rate.
( Liu et al., 2023 )

SDN1
CRISPR/Cas

Chinese Academy of Agricultural Sciences
Tobacco Research Institute
Key Laboratory of Tobacco Genetic Improvement and Biotechnology
Shenzhen Yupeng Technology Co.
Sichuan Tobacco Corporation, China

Reduced cadmium (Cd) accumulation and enhanceed Cd resistance. Cd accumulation in the edible parts of the plant pose potential risks to human health.
( Zheng et al., 2024 )

SDN1
CRISPR/Cas

Zhengzhou Tobacco Research Institute of CNTC
China Tobacco Yunnan Industrial Co. LTD
Beijing Life Science Academy (BLSA)
Zhengzhou University, China

Traits related to improved food/feed quality

Ultra-low nicotine level
( Burner et al., 2022 )

SDN1
CRISPR/Cas

North Carolina State University, USA

Improved cadmium tolerance by reducing the Cd transport from vacuole to cytosol in tobacco leaves.
( Jia et al., 2022 )

SDN1
CRISPR/Cas

Henan Agricultural University
Xiamen University, China

High-amylose content (up to 56% in apparent amylose content) and resistant starch (up to 35%).
( Luo et al., 2021 )

SDN1
CRISPR/Cas

Chinese Academy of Sciences
Shanghai Sanshu Biotechnology Co.,
Guangxi Subtropical Crops Research Institute, China

Fine-tuning sugar content. Consumer preference varies along regional, cultural, and age lines, thus the solution is to create a continuum of phenotypic “taste” changes
( Xing et al., 2020 )

Chinese Academy of Sciences
China Agricultural University, China

Attenuated toxic cyanogen production. Cassava produces toxic cyanogenic compounds and requires food processing for safe consumption.
( Gomez et al., 2021 )

SDN1
CRISPR/Cas

University of California
Donald Danforth Plant Science Center
Lawrence Berkeley National Laboratory
Okinawa Institute of Science and Technology Graduate University
Chan-Zuckerberg BioHub, USA

Glucoraphanin(GR)-enriched broccoli. Broccoli contains important nutritional components and beneficial phytochemicals. GR, a major glucosinolate (GSL), protects the body against several chronic diseases.
( Kim et al., 2022 )

SDN1
CRISPR/Cas

Sejong University
Jeonbuk National University
Korea Research Institute of Bioscience and Biotechnology
Asia Seed Company Limited, South Korea

Promoted phenolic acid biosynthesis. Salvia is tradional Chinese medicine with great medical value to treat cardio- and cerebrovascular diseases. Phenolic acids make up a big part of the bioactive compounds.
( Shi et al., 2021 )

SDN1
CRISPR/Cas

East China University of Science and Technology
Zhejiang Chinese Medical University, China
University of Hawaii at Manoa, USA

Reduce or eliminate amylose content in root starch. Amylose influences the physicochemical properties of starch during cooking and processing.
( Bull et al., 2018 )

SDN1
CRISPR/Cas

Institute of Molecular Plant Biology, Switzerland

Increased phosphorus and anthocyanin content.
( Zhang et al., 2023 )

SDN1
CRISPR/Cas

Shenyang Agricultural University
Ministry of Education, China

Glossy green phenotype and reduced cuticular wax load.
( Liu et al., 2023 )

SDN1
CRISPR/Cas

Chinese Academy of Agricultural Sciences
Hunan Agricultural University
Tianjin Kernel Vegetable Research Institute, China

Increased phosphorus content and improved fruit quality.
( Zhang et al., 2023 )

SDN1
CRISPR/Cas

Shenyang Agricultural University
Ministry of Education, China

Reduced nicotine levels.
Nicotine is an addictive compound leading to severe diseases.
( Singh et al., 2023 )

SDN1
CRISPR/Cas

CSIR-National Botanical Research Institute
Academy of Scientific and Innovative Research (AcSIR)
Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), India

Increased potassium concentrations (K+). Potassium is crucial for improving the quality of tobacco.
( Gao et al., 2024 )

SDN1
CRISPR/Cas

Yunnan Academy of Tobacco Agricultural Sciences/National Tobacco Genetic Engineering
Research Center
Chinese Academy of Agricultural Sciences, China

Reduced nicotine levels. Nicotine is the addictive component in tobacco.
( Jeong et al., 2024 )

SDN1
CRISPR/Cas

Nulla Bio Inc.
Gyeongsang National University
Gyeongsang National University 501 Jinju-daero, South Korea

Traits related to increased plant yield and growth

Faster seedling growth.
( Zhou et al., 2018 )

SDN1
CRISPR/Cas

University of Maryland, USA

Transformation of a climbing woody perennial, developing axillary inflorescences after many years of juvenility, into a compact plant with rapid terminal flower and fruit development.
( Varkonyi-Gasic et al., 2022 )

SDN1
CRISPR/Cas

The New Zealand Institute for Plant &
Food Research Limited (Plant &
Food Research), University of Auckland, New Zealand

Significantly higher potassium accumulation. Potassium ions are essential nutrients for growth and development of tobacco.
( Gao et al., 2024 )

SDN1
CRISPR/Cas

Yunnan Academy of Tobacco Agricultural Sciences/National Tobacco Genetic Engineering Research Center
Chinese Academy of Agricultural Sciences, China

Traits related to industrial utilization

Cytoplasmic male sterility.
( Chang et al., 2022 )

SDN1
CRISPR/Cas

Northwest Institute of Plateau Biology Chinese Academy of Sciences, China

Establishment of maternal haploid induction. Doubled haploid technology is used to obtain homozygous lines in a single generation. This technique significantly accelerates the crop breeding trajectory.
( Zhong et al., 2022 )

SDN1
CRISPR/Cas

China Agricultural University, China
Wageningen University and Research, The Netherlands

Accumulate low levels of alkaloids. Nicotine is the most abundant alkaloid produced in tobacco plants. Switching to cigarettes containing levels of nicotine below the level of sustaining an addiction response will smoke less and/or find it easier to quit. Possibly, the US Food and Drug Administration (FDA) may mandate such reductions in future cigarette products.
( Smith et al., 2022 )

SDN1
CRISPR/Cas

North Carolina State University, USA

Glycoproteins without plant-specific glycans. Plants or plant cells can be used to produce pharmacological glycoproteins, for example antibodies or vaccines. However these proteins carry N-glycans with plant-typical residues [β(1,2)-xylose and core α(1,3)-fucose]. This plant-specific glycans can greatly impact the immunogenicity, allergenicity, or activity of the protein.
( Mercx et al., 2017 )

SDN1
CRISPR/Cas

Université catholique de Louvain
Université de Liège, Belgium

Nicotine-free tobacco.
( Schachtsiek et al., 2019 )

SDN1
CRISPR/Cas

TU Dortmund University, Germany

Accelerate flowering, a rare event under glasshouse conditions. Modified starch.
( Bull et al., 2018 )

SDN3
CRISPR/Cas

Institute of Molecular Plant Biology, Switzerland

Traits related to herbicide tolerance

Herbicide tolerance: glyphosate
(Hummel et al., 2017)

SDN3
CRISPR/Cas

Donald Danforth Plant Science Center, St. Louis, USA

Traits related to product color/flavour

Albino phenotype.
( Wilson et al., 2019 )

SDN1
CRISPR/Cas

NIAB EMR, UK

Albino phenotype.
( Wang et al., 2018 )

SDN1
CRISPR/Cas

Provincial Key Laboratory of Applied Botany
Guangdong Provincial Key Laboratory of Applied Botany
University of Chinese Academy of Sciences, China

Reduced citrate content. Citrate is a common primary metabolite which often characterizes fruit flavour.
( Fu et al., 2023 )

SDN1
CRISPR/Cas

Zhejiang University, China
University of Florida, USA
The New Zealand Institute for Plant &
Food Research Limited (Plant &
Food Research) Mt Albert
University of Auckland, New Zealand

Traits related to storage performance

Extended root shelf-life, which decreases its wastage.
( Mukami et al., 2023 )

SDN1
CRISPR/Cas

Kenyatta University
Jomo Kenyatta University of Agriculture Technology
Pwani University Kilifi, Kenya

Traits categories

Genome Editing Technique

Countries

Plant

Sdn Type

Traits related to biotic stress tolerance

Traits related to abiotic stress tolerance

Traits related to improved food/feed quality

Traits related to increased plant yield and growth

Traits related to industrial utilization

Traits related to herbicide tolerance

Traits related to product color/flavour

Traits related to storage performance